Effective Delivery of Endogenous Antioxidants Ameliorates Diabetic Nephropathy
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چکیده
منابع مشابه
Effective Delivery of Endogenous Antioxidants Ameliorates Diabetic Nephropathy
BACKGROUND Diabetic nephropathy (DN) is thought to be partially due to the injury of renal cells and the renal micro-environment by free radicals. Free radial scavenging agents that inhibit free radical damage may well prevent the development of underlying conditions such as mesangial expansion (by inhibiting extracellular matrix expression) in these patients. METHODS Using techniques for int...
متن کاملDiabetic nephropathy and antioxidants.
CONTEXT Oxidative stress has crucial role in pathogenesis of diabetic nephropathy (DN). Despite satisfactory results from antioxidant therapy in rodent, antioxidant therapy showed conflicting results in combat with DN in diabetic patients. EVIDENCE ACQUISITIONS Directory of Open Access Journals (DOAJ), Google Scholar,Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched. RESULTS...
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Objective(s) Oxidative stress plays an important role in diabetic nephropathy pathogenesis. Rosmarinic acid, a plant phenolic compound, was first used as an antioxidant agent for inhibition of diabetic nephropathy. Material and Methods Forty male rats were uninephrectomized from the left flank.The rats were divided in four groups randomly; group one as control, group two diabetic untreatment...
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Diabetes mellitus (DM) is a group of metabolic diseases characterized with inappropriate hyperglycemia due to either a deficiency of insulin secretion or a combination of insulin re‐ sistance and inadequate insulin secretion (Masharani, 2008). Type 1 diabetes is caused by ab‐ solute deficiency of insulin secretion. Individuals at risk of developing this type of diabetes are found with serologic...
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Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea D iabetic nephropathy is one of the major long-term complications of diabetes mellitus and has emerged as a leading cause of end-stage renal disease in certain parts of the world (1) including Korea (2). Data from the Diabetes Control and Complications Trial (3) established hyperglycemia as the main determinant of i...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0130815